Stem Cell Therapy
Los Angeles
WHAT ARE
STEM CELLS?
Stem cells are found throughout the body and specifically mesenchymal stem cells (MSC) are specialized cells that have been shown in clinical research to possibly have anti-inflammatory, immunomodulatory, and regenerative properties. They are also reported to have anti-scarring, antimicrobial, and anti-oxidative effects. Stem cells used in the clinical setting and with clinical research are typically obtained from adipose (fat), bone marrow, and birthing tissue including amniotic fluid, amnion, umbilical cord blood and Wharton’s jelly. The stem cells are either used in its original state during procurement, or they can be culture-expanded to larger quantities.
HOW DO
STEM CELLS WORK?
Mesenchymal stem cells have been shown in research to differentiate into various types of tissue and have paracrine effects. These paracrine effects involve the release of bioactive molecules that can stimulate and communicate with neighboring cells and support the body’s natural healing processes.
BENEFITS OF
STEM CELLS
Because of the dynamic properties of MSC’s, researchers worldwide have been investigating the use of stem cells since the 1960s. Promising findings through research for many different health problems has fueled more interest and funding for additional clinical studies to find ways to utilize the unique properties of stem cells. Over the last decade, over 1000 human clinical research trials involving close to 50,000 patients evaluating stem cell use has been documented worldwide demonstrating its safety profile and promising results. Clinical research of stem cells have mainly focused on people who are suffering from difficult wounds, physical ailments, and diseases that are often inadequately addressed with conventional medicine, including pharmaceutical drugs and surgery.
Individuals may consider stem cell therapy as part of a broader approach designed to support the body’s natural healing and recovery processes. Stem cells are not presented as a cure or as a treatment for any specific disease or condition. Rather, they may be used with the goal of supporting tissue health and the body’s natural response to injury. Some individuals explore this therapy when symptoms persist despite conservative measures such as rest, physical therapy, activity modification, or other approaches, or when they are looking for non-surgical options. A consultation with Dr. Yoon is recommended to review the individual’s history, current condition, imaging, and goals to determine whether stem cell therapy is appropriate.
The consultation with Dr. Yoon will include a thorough evaluation and discussion of your condition, goals, and available options and if stem cells can help support the injury. If stem cell therapy is pursued, Dr. Yoon’s office will provide a pre- and post- therapy handout. Additional prescriptions may also include orthotics and braces, biomechanics evaluations, physical therapy, and other supportive measures when appropriate. Because each patient and injury is different, expected outcomes and recovery recommendations will be discussed individually. Follow-up evaluations will be scheduled to assess progress and help optimize the overall recovery plan.
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WHY CHOOSE DR. STEVE YOON FOR STEM CELL Therapy?
Dr. Steve Yoon is a highly regarded biologics expert utilizing stem cells in professional sports making him a top choice for stem cell therapy for patients in Los Angeles and around the country. He has extensive experience utilizing stem cells while in his role as Director of Clinical Regenerative Medicine at the Cedars Sinai Kerlan Jobe Institute and as a treating consultant for the vast majority of professional sports teams and sports agencies throughout the country. Dr. Yoon has successfully helped patients over two decades while specializing in the use of stem cells and other regenerative therapies to assist with recovery and performance. His personalized and tailored approach with patients and helping them with their quality of life has earned him numerous honors including being recognized annually in Los Angeles as a Super Doctor as well as a Top Doctor nationally by Castle Connolly.
RESEARCH ARTICLES
Zhu C, Wu W, Qu X. Mesenchymal stem cells in osteoarthritis therapy: a review. Am J Transl Res. 2021;13(2):448-461.
Wiggers TGH, Winters M, Van den Boom NAC, Haisma HJ, Moen MH. Autologous stem cell therapy in knee osteoarthritis: a systematic review of randomised controlled trials. Br J Sports Med. 2021;55(20):1161-1169. doi:10.1136/bjsports-2020-103671.
Long Z, Zhang M, Zhang T, et al. The effectiveness and safety of mesenchymal stem cells in the treatment of osteoarthritis: a systematic review and meta-analysis of 28 randomized controlled trials. Stem Cells Int. 2022;2022:6151866. doi:10.1155/2022/6151866.
Sadeghirad B, Rehman Y, Khosravirad A, et al. Mesenchymal stem cells for chronic knee pain secondary to osteoarthritis: a systematic review and meta-analysis of randomized trials. Osteoarthritis Cartilage. 2024;32(10):1207-1219. doi:10.1016/j.joca.2024.04.021.
Tang X, Huang H, Hao L. Decadal analysis of efficacy and safety profiles of mesenchymal stem cells from varied sources in knee osteoarthritis patients: a systematic review and network meta-analysis. Exp Gerontol. 2024;192:112460. doi:10.1016/j.exger.2024.112460.
Tian X, Qu Z, Ying C, et al. Relative efficacy and safety of mesenchymal stem cells for osteoarthritis: a systematic review and meta-analysis of randomized controlled trials. Front Endocrinol (Lausanne). 2024;15:1366297. doi:10.3389/fendo.2024.1366297.
Trapana J, Weinerman J, Lee D, et al. Cell-based therapy in the treatment of musculoskeletal diseases. Stem Cells Transl Med. 2024;13(10):959-978. doi:10.1093/stcltm/szae049.
Kyriakidis T, Ferenets R, Owczarek M, et al. Stem cells for the treatment of early to moderate osteoarthritis of the knee: a systematic review. J Exp Orthop. 2023;10(1):38. doi:10.1186/s40634-023-00665-1.