Alpha-2 macroglobulin is a plasma protein in the blood that is produced by the liver. It is also naturally synthesized by other elements in the blood. It is one of the largest and heaviest proteins your body naturally produces. Research suggests that this protein may halt progressive damage of arthritic joints.

What is A2M?

Alpha-2 macroglobulin is a plasma protein found in the blood. It is a protease inhibitor that inactivates various proteases that have been associated with cartilage destruction and cartilage loss. Research studies have shown that A2M can help protect cartilage cells (chondrocytes) and inhibit some of the factors that break down cartilage. It is also associated with inhibiting the inflammation that can occur in degenerative joint disease. The protective role of A2M and its associated anti-inflammatory effects can thus help inhibit the progression of chondromalacia and osteoarthritis, reduce pain and restore function to the joint.

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How long does it take to see any results?

A2M injections may begin relieving pain within weeks after the injection but typically it may take up to eight to twelve weeks before there is an initial noticeable effect.

Will I need repeat injections in the future?

For chronic conditions such as osteoarthritis and chondromalacia of the joints, A2M treatment combined with rehabilitation may not necessitate further treatment. It is possible that repeat supplemental treatment may be needed again in the future due the joint’s chronic degenerative condition. The type of supplemental treatment would be determined during follow-up.

Is A2M covered by my insurance?

A2M is not covered by medical insurance and is not billed to your insurance provider. A cash payment will be necessary prior to your procedure.

What A2M can do for osteoarthritis

A2M is designed by nature to inhibit cartilage catabolism (destruction) and inflammation created by proteases. It has been seen to neutralize and halt the progression cartilage degeneration. A2M not only blocks the activity, but some research has shown that it may well suppress the genetic triggers that initiated the disease.

You can think of A2M as a master inhibitor for a whole range of proteinases and many of their processes. When it is doing this, it is bringing about a balance to the complex chemical and atomic processes of the body.

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